Puerto Rico is one main island plus Vieques and Culebra. You fly into San Juan (SJU), pay in US dollars, and go through US entry rules. The rainforest on the east, the winter surf on the west, and the Spanish Virgin Islands are different trips. Don't try to drive all four in a long weekend.
San Juan, El Yunque and the east
San Juan & the Northeast is the gateway. Sleep in San Juan for the city and a short first day. El Yunque & Fajardo is the wet forest and Laguna Grande, the bio bay you kayak on a dark night. Hiking in El Yunque is humid, often busy, and some gates use timed entry, so check the listing or the forest site before you drive up. Camuy caves and the north coast are day trips from here, not a second holiday.
West coast surf and the dry south
West Coast is Rincón & Porta del Sol: winter surfing at Rincón, Aguadilla and Isabela, plus northwest scuba when the swell isn't smashing the entries. Cabo Rojo is cliffs and salt flats at the same end of the island. Mona is not a casual day trip. South Coast & Cordillera is drier. Ponce & Guánica has dry-forest hiking, La Parguera boats and another bio bay. Cordillera Central is coffee country and Toro Negro, with cooler nights. That's a mountain base, not a beach add-on after a Ponce lunch.
Vieques and Culebra
Vieques & Culebra need their own nights. Ferries leave from Ceiba, not Old San Juan. Small planes exist if you'd rather not sit on the dock. Vieques is Mosquito Bay, often the brightest of the three bio bays, still dependent on the moon and recent rain. Culebra is Flamenco Beach and snorkelling at Luis Peña. Don't book a same-day return and a night kayak.
Where to base yourself
San Juan for the first nights and El Yunque days. Rincón if surf is the week. A south-coast lodge if Guánica and La Parguera are the point. Sleep on Vieques or Culebra if those islands are why you came. Crossing the main island takes longer than the map suggests once you hit San Juan rush hour.
Booking and getting started on adventuro
Bio-bay kayaking, intro snorkel and many rainforest walks are beginner-friendly if you swim and can handle the heat. Certified diving, exposed reef and bigger winter surf sit at improver and advanced. Open the Book here tab for live dates. Ferry seats and El Yunque access are what get tight, not the island itself.